Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts

authored by: Nils Stanislawski, Fabian Cholewa, Henrik Heymann, Xenia Kraus, Sebastian Heene, Martin Witt, Stefanie Thoms, Cornelia Blume, Holger Blume
Abstract: In an aging society, diseases associated with irreversible damage of organs are frequent. An increasing percentage of patients requires bioartificial tissue or organ substitutes. Tissue engineering products depend on a well-defined process to ensure successful cultivation while meeting high regulatory demands. The goal of the presented work is the development of a bioreactor system for the cultivation of tissue-engineered vascular grafts (TEVGs) for autologous implantation and transition from a lab scale setup to standardized production. Key characteristics include (i) the automated reliable monitoring and control of a wide-range of parameters regarding implant conditioning, (ii) easy and sterile setup and operation, (iii) reasonable costs of disposables, and (iv) parallelization of automated cultivation processes. The presented prototype bioreactor system provides comprehensive physiologically conditioning, sensing, and imaging functionality to meet all requirements for the successful cultivation of vascular grafts on a productional scale.
Organisation(s): Institute of Microelectronic Systems
Institute of Technical Chemistry
Type: Conference contribution
Pages: 2257-2261
No. of pages: 5
Publication date: 2020
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Signal Processing, Biomedical Engineering, Computer Vision and Pattern Recognition, Health Informatics
Electronic version(s): https://doi.org/10.1109/embc44109.2020.9175340 (Access: Closed)